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. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: Semin Cell Dev Biol. 2020 Apr 2;105:43–53. doi: 10.1016/j.semcdb.2020.03.002

Fig. 1.

Fig. 1.

Cryo-EM structures of human γ-secretase in complex with APP-C83 (left, PDB bank ID 6IYC) and Notch-100 (right, PDB bank ID 6IDF). Color: APP-C83/Notch-100 in red, PS1 in light blue, Aph1 in bright orange, and Pen2 in pale yellow and Nicastrin in green.