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. Author manuscript; available in PMC: 2021 Mar 23.
Published in final edited form as: Adv Drug Deliv Rev. 2020 Mar 23;153:147–168. doi: 10.1016/j.addr.2020.03.003

Figure 11.

Figure 11.

(a) SRS images of SC, SG, AD and SCF layers in mouse epidermis (on the left side of each red box) and segmentation of the lipid-rich areas using 4 in-house-trained U-Net algorithms (on the right side of each red box). (b) Relative uptake of ruxolitinib over time in transcutol and a gel formulation in the lipid-rich regions of an SC image. (c) Pearson’s correlation coefficient for 10 uptake patterns similar to what is shown in (a) for both ruxolitinib and BMDP-D in transcutol and gel showing a statistically significant difference between the two vehicles. (p < 0.05). (d, e) AUC calculated for the same experiments as in (c) but for the AD and SCF shows a non-significant difference between the two vehicles. Taken from [195] with permission.