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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: J Allergy Clin Immunol. 2020 Apr 19;146(3):555–570. doi: 10.1016/j.jaci.2020.03.037

Figure 2. Antigen-specific Th1 and Th2 effectors are armed for airway recruitment in asthmatics.

Figure 2.

(a) Representative contour plots of RV-specific T cells overlaid on total CD4+ T cells, analyzed for CCR7 and CD45RO expression. (b & c) Percentage of RV-specific, allergen-specific, and total CD4+ T cells expressing CD45RO (b) or TCM and TEM phenotypes (c). Control, n ≥6; asthma, n ≥22. (Box-and-whiskers, Kruskal-Wallis & Mann-Whitney). (d) Representative plots showing marker expression on antigen-specific and total CD4+ T cells in an asthmatic subject. (e) Comparison of RV- and allergen-specific TCM and TEM surface markers within asthmatic subjects (Box-and-whiskers, Wilcoxon). (f) SPICE plots showing average signatures of RV-specific and allergen-specific TCM and TEM cells in asthmatics and controls. Asterisks denote significant differences for TCM vs TEM subsets within each group. Samples with insufficient numbers of tetramer+ cells were excluded from phenotypic analyses. nd, not determined. *p ≤0.05, **p ≤0.01, ***p ≤0.001.