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. 2020 Sep 10;10:14929. doi: 10.1038/s41598-020-71879-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phased activity of TBI versus sham mice in IntelliCages. (A,B) Time courses of corner Visits/h, Visits without Licks/h (SVisits) and Lickings per Visit in TBI/sham cohort-1 during the first (A) and second round (B) of place preference learning (PPL1, PPL2) and the respective reversal learning tasks (REV1, REV2), respectively. The data show the mean ± SEM of n = 10 sham and n = 21 TBI mice. One and two animals respectively dropped out during PPL1 or REV1 because of general health problems. SVisits are visits without attempt (nosepoke) to get reward. Asterisks above the X-axis indicate significant differences of the areas under the curve between groups as assessed by 2-way ANOVAs with the factors "group" and "time" (day or night), *P < 0.05, **P < 0.01, ***P < 0.001. Data were analyzed in IntelliCage Plus software 2019 and FlowR 2017 (XBehavior; https://www.xbehavior.com), exported as tab-separated txt files, imported in Microsoft Excel 2016, and Graphs were created with Graphpad Prism 8.4 (https://www.graphpad.com) and exported as emf. Graphs were arranged and labeled in Adobe Illustrator CC2020 (https://www.adobe.com/de), and exported to TIFF format.