Figure 1.

Schematic representation of the experimental design for H. erinaceus treatments and a testing of cerebellar ataxia functions in rat model of 3-AP-induced cerebellar ataxia (A). Rats from each group were placed on the lane of the rotarod apparatus, respectively (B). Rats were trained on the rotarod and baseline performance was assessed on day -3 and day -2 prior to the 3-AP injection (C). Accelerated rotarod evaluation of the motor deficits by latency to fall (Rank) (D), percentage of deficit (Rank) (E), and rod test by latency to fall for the assessment of balance (F). The endpoints were rank transformed, and results were presented as mean individual data points with 95% confidence interval. All statistical values have been adjusted by Bonferroni correction for multiple comparisons. Indicators: # Significantly different from the non-3-AP control group. p values < 0.05.