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. 2020 Sep 10;11(9):737. doi: 10.1038/s41419-020-02965-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Expression of miR-378-3p in mouse ovaries from 16.5 dpc to 3 dpp detected by miRNA qRT-PCR. The expression level of miR-378-3p significantly increased in the ovaries from 17.5 dpc to 3 dpp compared with that of 16.5 dpc; b Expression of miR-378-3p significantly increased after rapamycin treatment; c Expression of miR-378-3p significantly decreased after 3-methyladenine treatment; d Immunofluorescence staining of in vitro cultured mouse ovaries with rapamycin and 3-MA, respectively. Germ cells were stained red with anti-Mvh antibody, nuclei were stained blue with Hochest 33342; e Rapamycin increased the percentage of primordial follicle; f 3-MA decreased the percentage of primordial follicle; g Western blotting of apoptosis-related proteins CASP9, CASP3, BAX and BCL-2 after rapamycin treatment; h Western blotting of autophagy-related proteins PDK1, mTOR and LC3B after rapamycin treatment; i Western blotting of apoptosis-related proteins CASP9, CASP3, BAX, and BCL-2 after 3-MA treatment; j Western blotting of autophagy-related proteins PDK1, mTOR, and LC3B after 3-MA treatment.