TABLE 2.

Patient-Reported Outcomes Measurement Information System (PROMIS)

	n	Baseline	n	6 Weeks	n	12 Weeks
Pediatric Physical
Function – Upper
Extremity T Score
Healthy	23	50.6 ± 8.8	20	52.5 ± 6.7	19	53.2 ± 6.4*
HbSSa	21	45.9 ± 10.9	21	47.8 ± 9.5	20	51.2 ± 8.7**
Pediatric Physical
Function – Mobility
T Score
Healthy	23	57.8 ± 3.3	20	58.1 ± 2.9	19	57.5 ± 3.7
HbSS	21	53.1 ± 6.2*	21	55.2 ± 5.1**	20	55.7 ± 5.4
Pediatric Peer
Relationships T Score
Healthy	23	56.0 ± 7.3	20	57.2 ± 7.8	19	56.1 ± 9.2
HbSS	21	56.9 ± 7.1	21	58.2 ± 8.5	20	57.8 ± 11.0
Pediatric Pain Impact
T Score
Healthy	23	48.6 ± 8.7	20	49.9 ± 10.1	19	48.9 ± 7.3
HbSS	21	54.4 ± 13.3*	21	52.7 ± 13.2**	20	48.4 ± 14.8‡‡
Pediatric Fatigue
T Score
Healthy	23	40.3 ± 10.3	20	43.3 ± 12.4	19	36.3 ± 10.0‡
HbSS	21	51.7 ± 11.4*	21	48.6 ± 10.2	20	46.4 ± 14.0‡‡***
Pediatric Depressive
Symptoms T Score
Healthy	23	41.5 ± 8.2	20	37.4 ± 7.6†	19	39.9 ± 9.4
HbSS	21	43.1 ± 8.1	21	39.1 ± 5.8††	20	39.1 ± 7.3‡‡

^aHbSS, type SS sickle cell disease.

^*P<0.05, HbSS vs. Healthy at baseline.

^**P<0.05, HbSS vs. Healthy at 6 Weeks.

^***P<0.05, HbSS vs. Healthy at 12 Weeks.

^†P<0.05, 6 Weeks vs. Baseline in Healthy.

^††P<0.05, 6 Weeks vs. Baseline in HbSS.

^‡P<0.05, 12 Weeks vs. Baseline in Healthy.

^‡‡P<0.05, 12 Weeks vs. Baseline in HbSS.