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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Cell Metab. 2020 Jul 14;32(3):341–352. doi: 10.1016/j.cmet.2020.06.019

Figure 1. Metabolism Supports Macromolecule Synthesis for Growth.

Figure 1.

Cancer cells upregulate both glycolysis and TCA cycle metabolism in order to provide the substrates required for synthesis of macromolecules such as lipids and nucleotides that are required for cell proliferation. Multiple substrates feed into these biosynthetic pathways, thus providing cancer cells with metabolic flexibility to support tumor growth.