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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Cell Metab. 2020 Jul 14;32(3):341–352. doi: 10.1016/j.cmet.2020.06.019

Figure 4. TCA Cycle Feeds Multiple Biosynthetic Pathways.

Figure 4.

Mitochondrial TCA cycle intermediates are utilized as precursors for biosynthetic purposes. This depletion of carbons requires replenishment, i.e., anaplerosis, usually from glutaminolysis and/or pyruvate carboxylase. Multiple inhibitors targeting different steps within the cycle have shown promise in phase I and II clinical trials.