Table 2. Association of Alzheimer’s disease polygenic risk score with MCI sub-groups based on the Rey Auditory Verbal Learning Test (AVLT).

Full regression results of logistic regression models. Odds ratios represent the odds of being in the AVLT-impaired group compared to the AVLT-normal group. The table on the left displays results from the model including the full Alzheimer’s disease polygenic risk score (AD-PRS). The table on the right displays results from the “No APOE’ Ad-PRS which excludes SNPs in the region of the APOE gene as well as a separate variable coding for the presence versus absence of the directly genotyped APOE-ε4+ allele. Both models included age and the first ten genetic principal components (PC) as covariates.

Predictors	Odds Ratios	95 % CI	p	Predictors	Odds Ratios	95% CI	p
AD-PRS	1.80	1.35 – 2.38	<0.001	AD-PRS No APOE	1.71	1.28 – 2.28	<0.001
Age	0.66	0.50 – 0.87	0.003	APOE-ε4+	2.14	1.24 – 3.69	0.006
PC 1	1.30	1.00 – 1.68	0.05	Age	0.68	0.52 – 0.91	0.008
PC 2	1.16	0.89 – 1.52	0.281	PC 1	1.20	0.92 – 1.57	0.184
PC 3	0.96	0.70 – 1.32	0.803	PC 2	1.17	0.89 – 1.55	0.26
PC 4	0.97	0.71 – 1.32	0.844	PC 3	0.98	0.71 – 1.35	0.881
PC 5	0.92	0.71 – 1.20	0.544	PC 4	0.97	0.71 – 1.32	0.836
PC 6	1.03	0.79 – 1.33	0.839	PC 5	0.92	0.71 – 1.21	0.557
PC 7	1.00	0.77 – 1.29	0.97	PC 6	1.00	0.77 – 1.31	0.983
PC 8	0.81	0.63 – 1.05	0.12	PC 7	0.99	0.76 – 1.28	0.914
PC 9	0.80	0.61 – 1.04	0.099	PC 8	0.82	0.63 – 1.07	0.139
PC 10	1.19	0.91 – 1.56	0.199	PC 9	0.79	0.60 – 1.03	0.086
				PC 10	1.20	0.91 – 1.58	0.191