. Author manuscript; available in PMC: 2021 Jul 1.

Published in final edited form as: Alzheimer Dis Assoc Disord. 2020 Jul-Sep;34(3):212–219. doi: 10.1097/WAD.0000000000000385

Table 2.

Parameter estimates for AD biomarker outcomes: AHA exercise groups.

Effect	APOE: Aβ₄₂	APOE: tau	APOE: Ptau₁₈₁	APOE: PET-PIB	BDNF: Aβ₄₂	BDNF: tau	BDNF: Ptau₁₈₁	BDNF: PET-PIB
Time	−35.4 (4.7)^*	5.4 (1.8)^*	.9 (.3)^*	.004 (.002)^*	−35.3 (4.7)^*	8.3 (1.5)^*	1.4 (.2)^*	.009 (.002)^*
Exercise group	−48.1 (80.1)	−35.6 (30.1)	−2.0 (5.1)	−.02 (.03)	−3.0 (83.6)	−45.2 (30.3)	−3.1 (4.9)	−.07 (.03)
APOE or BDNF Genotype	−241.5 (75.4)^*	88.0 (29.8)^*	10.7 (5.0)^*	.10 (.03)^*	−62.9 (78.5)	20.9 (28.5)	5.6 (4.7)	.03 (.03)
CDR change	254.6 (216.4)	132.5 (80.0)	16.6 (13.6)	.11 (.04)^*	252.9 (227.9)	121.2 (81.1)	14.2 (13.4)	.14 (.04)^*
Sex	39.4 (84.5)	28.1 (31.5)	7.0 (5.3)	−.04 (.03)	87.8 (88.4)	17.6 (31.6)	5.9 (5.2)	−.05 (.03)
Age	−6.6 (5.0)	6.1 (1.9)^*	.7 (.3)^*	.002 (.001)	−6.4 (5.2)	6.1 (1.9)^*	.8 (.3)^*	.002 (.001)
Education	14.0 (15.2)	−8.0 (5.7)	−1.2 (.9)	.002 (.004)	20.3 (15.9)	−9.5 (5.7)	−1.4 (.9)	.002 (.005)
Health composite	−53.1 (38.3)	10.0 (14.5)	2.4 (2.4)	.0004 (.01)	−35.2 (39.9)	4.6 (14.7)	1.9 (2.4)	−.001 (.01)
Exercise - 1^st Outcome Delay	7.0 (30.4)	2.3 (12.4)	−1.2 (2.0)	−.006 (.008)	9.1 (32.2)	1.3 (12.9)	−1.6 (2.1)	−.005 (.009)
Time × Exercise	---	---	---	---	---	---	---	---
Exercise × Genotype	---	---	---	---	---	---	---	.14 (.06)^*
Time × APOE Genotype	---	7.9 (2.9)^*	1.1 (.5)^*	.02 (.004)^*	---	---	---	---
Time × Exercise × Genotype	---	---	---	---	---	---	---	---

Notes: Data represent parameter estimates (standard errors) for the final model;

= p<.05,

^†

= p<.06; --- = not included in final model.