Table 1. Ingenuity canonical pathways of orthotopic allograft model MSGE.

Ingenuity Pathway Analysis results showing the top 10 significantly enriched pathways by orthotopic-specific MSGE of 4T1, 6DT1, and Mvt1. Significance of enrichment for this pathway in each the gene set is indicated by the -log(p-value) where >1.3 is significant.

4T1	−log (p-value)	6D1	−log (p-value)	Mvt1	−log (p-value)
Granulocyte Adhesion and Diapedesis	9.25	Th1 and Th2 Activation Pathway	17.3	Antigen Presentation Pathway	7.19
Agranulocyte Adhesion and Diapedesis	7.16	Th1 Pathway	14.9	Allograft Rejection Signaling	5.79
Th1 and Th2 Activation Pathway	7.14	Th2 Pathway	14.2	OX40 Signaling Pathway	4
VDR/RXR Activation	6.89	iCOS-iCOSL Signaling in T Helper Cells	11.8	Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells	3.27
Th2 Pathway	6.83	Altered T Cell and B Cell Signaling in Rheumatoid Arthritis	11.5	Cdc42 Signaling	3.21
T Helper Cell Differentiation	6.2	Granulocyte Adhesion and Diapedesis	11.3	Graft-versus-Host Disease Signaling	2.97
LXR/RXR Activation	4.97	Type I Diabetes Mellitus Signaling	11	Autoimmune Thyroid Disease Signaling	2.95
Th1 Pathway	4.97	CD28 Signaling in T Helper Cells	10.9	Protein Ubiquitination Pathway	2.59
iCOS-iCOSL Signaling in T Helper Cells	4.54	T Helper Cell Differentiation	10.8	Crosstalk between Dendritic Cells and Natural Killer Cells	2.44
Nur77 Signaling in T Lymphocytes	4.09	Dendritic Cell Maturation	10.4	Systemic Lupus Erythematosus In T Cell Signaling Pathway	2.35