Table 2:

Univariate and multivariate logistic regression analysis for lymph node metastasis in training and validation cohorts

	Univariate analysis			Multivariate analysis
Characteristics	OR	95% CI	P-value	OR	95% CI	P-value
Training cohort (n = 157)
Age (≥70 vs. <70 years)	0.55	0.29–1.04	0.07	0.53	0.23–1.23	0.14
Gender (Female vs. Male)	0.67	0.35–1.26	0.21	0.45	0.19–1.06	0.07
CA19–9 (≥ 71.5 vs. < 71.5 U/mL)	2.44	1.28–4.66	< 0.01	2.18	0.92–5.14	0.08
Location (Pbt vs. Ph)	0.32	0.16–0.63	< 0.01	0.21	0.09–0.53	< 0.01
Tumor size (≥ 28 vs. < 28 mm)	1.75	0.91–3.38	0.01	1.85	0.78–4.41	0.17
6-miRNA signature (High vs. Low risk)	33.36	9.57–116.23	< 0.01	19.93	7.55–52.62	< 0.01
Validation cohort (n = 107)
Age (≥70 vs. <70 years)	0.59	0.27–1.29	0.19	1.00	0.39–2.60	0.99
Gender (Female vs. Male)	0.94	0.44–2.04	0.88	1.11	0.43–2.83	0.83
CA19–9 (≥ 71.5 vs. < 71.5 U/mL)	2.75	1.20–6.30	0.02	1.55	0.58–4.13	0.38
Location (Pbt vs. Ph)	0.49	0.22–1.10	0.08	0.50	0.19–1.29	0.15
Tumor size (≥ 28 vs. < 28 mm)	2.14	0.98–4.68	0.06	1.75	0.66–4.65	0.26
6-miRNA signature (High vs. Low risk)	11.09	4.09–30.04	< 0.01	10.05	3.42–29.59	< 0.01

OR, odds ratio; CI, confidence interval