Skip to main content
. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Int J Radiat Biol. 2020 Feb 25;97(8):1121–1128. doi: 10.1080/09553002.2020.1730014

Figure 3: Inhibition of Wee1 or Chk1 leads to further radiosensitization in HNSCC.

Figure 3:

(A) Cells were treated with 1μM niraparib (PARPi) alone or in combination with 200nM MK-8776 (Chk1i) or MK-1775 (Wee1i) for 1h then irradiated with 0–6Gy and replated 24h later for colony formation. (B) Plating efficiencies in HPV(−) FaDu (red) and HPV(+) SCC154 (blue) cell lines taken from CSAs shown in A. (C) Radiation dose enhancement factors (DEF) calculated at surviving fraction of 0.1 in HPV(−) FaDu and HPV(+) SCC154 cell lines.