Table 1.
Baseline characteristics of the deceased organ donors, stratified by donor culture results.
| Donor characteristica,b | No MDRO on donor culture (N 411) | MDRO on donor culture (N 29) | P valuec | ||
|---|---|---|---|---|---|
| Negative (N 173) | Non-MDRO positive (N 238) | MDR-GP (N 22) | MDR-GN (N 7) | ||
| Demographics, comorbidities | |||||
| Age (median, IQR) (years) | 41 (26–53) | 36 (27–52) | 32 (25–43) | 40 (23–50) | 0.102 |
| Chronic kidney disease | 4 (2%) | 4 (2%) | 1 (5%) | 0 (0%) | 0.789 |
| Diabetes mellitus | 21 (12%) | 26 (11%) | 3 (14%) | 1 (14%) | 0.961 |
| HCT | 1 (1%) | 1 (0.5%) | 0 (0%0 | 0 (0%) | 0.978 |
| DCD | 32 (19%) | 26 (11%) | 2 (9%) | 4 (57%) | 0.001 |
| ECD | 41 (24%) | 40 (17%) | 3 (14%) | 0 (0%) | 0.154 |
| PHS-increased risk | 52 (30%) | 84 (35%) | 11 (50%) | 2 (29%) | 0.263 |
| KDPI | 52 (32–79) | 48 (27–73) | 46 (30–69) | 54 (23–73) | 0.920 |
| Death mechanism | |||||
| Drug intoxication | 25 (14%) | 62 (26%) | 8 (36%) | 0 (0%) | 0.005 |
| Asphyxiation | 12 (7%) | 12 (5%) | 0 (0%) | 3 (43%) | <0.001 |
| Cardiovascular | 46 (27%) | 56 (24%) | 5 (23%) | 2 (29%) | 0.895 |
| Gunshot wound | 14 (8%) | 13 (5%) | 1 (5%) | 1 (14%) | 0.583 |
| Drug use | |||||
| Opiates (IDU or non-IDU) | 40 (23%) | 73 (31%) | 10 (45%) | 3 (43%) | 0.079 |
| IDU | 32 (19%) | 49 (21%) | 10 (45%) | 1 (14%) | 0.032 |
| Serologies and laboratory testing | |||||
| HCV seropositive | 14 (8%) | 14 (6%) | 4 (18%) | 1 (14%) | 0.167 |
| HCV viremia | 9 (6%) | 9 (4%) | 3 (16%) | 0 (0%) | 0.167 |
| HBV core antibody positive | 7 (4%) | 13 (5%) | 1 (5%) | 0 (0%) | 0.849 |
| Albumin (median, IQR) (g/dL) | 2.6 (2.3–2.9) | 2.5 (2.2–2.9) | 2.5 (2.1–2.8) | 1.9 (1.7–2.5) | 0.901 |
| Procedures | |||||
| ECMO | 4 (2%) | 7 (3%) | 0 (0%) | 0 (0%) | 0.811 |
| Open abdomen | 1 (1%) | 0 (0%) | 0 (0%) | 0 (0%) | 0.671 |
| Intra-aortic balloon pump | 1 (1%) | 3 (1%) | 0 (0%) | 0 (0%) | 0.849 |
| Exploratory laparotomy | 3 (2%) | 4 (2%) | 0 (0%) | 0 (0%) | 0.918 |
| Infections | |||||
| Lower respiratory tract infection | 30 (19%) | 97 (41%) | 13 (59%) | 4 (67%) | <0.001 |
| Meningitis | 0 (0%) | 1 (0.4%) | 0 (0%) | 0 (0%) | 0.837 |
| Donor management | |||||
| Length of stay (median, IQR) (days) | 3 (2–4) | 4 (3–6) | 5 (3–10) | 7 (4–25) | <0.001 |
| T4 protocol | 133 (77%) | 206 (87%) | 20 (91%) | 3 (43%) | 0.002 |
| Antibiotics during terminal hospitalization | |||||
| Any antibiotic | 165 (96%) | 235 (99%) | 21 (95%) | 6 (86%) | 0.076 |
| Number of antibiotics per donor (median, IQR) | 2 (1–2) | 2 (1–3) | 3 (2–3) | 2 (1–3) | 0.566 |
| Antibiotic days per donor (median, IQR) (days) | 4 (2–7) | 5 (4–8) | 7 (5–14) | 5 (4–8) | <0.001 |
| Length of antibiotics per donor (median, IQR) (days) | 2 (2–4) | 3 (2–4) | 3 (2–7) | 3 (2–4) | <0.001 |
Data are presented as numbers (percentages) except where noted.
Only those variables with a P value <0.20, those of notable biologic importance, and those included in the final multivariable models are shown in this table.
The provided P value reflects a comparison of all four exposure groups.
Abbreviations: DCD, donation after circulatory death; ECD, expanded criteria donor; ECMO, extracorporeal membrane oxygenation; HBV, hepatitis B virus; HCT, hematopoietic cell transplant; HCV, hepatitis C virus; IDU, injection drug use; IQR, interquartile range; KDPI, Kidney Donor Profile Index; MDRO, multidrug-resistant organism; MDR-GN, multidrug-resistant Gram-negative; MDR-GP, multidrug-resistant Gram-positive; PHS, Public Health Service