Table 2.

Multivariable Poisson regression evaluating the association between the number of organs transplanted per donor and (a) MDRO or (b) MDR-GN on donor hospital cultures

A. Any MDROa					B. MDR-GNb
Donor variable	IRR	95% CI	P value		Donor variable	IRR	95% CI	P value
MDRO on culture	1.15	0.99–1.33	0.068		MDR-GN on culture	0.43	0.39–0.48	<0.001
DCD	0.44	0.37–0.52	<0.001		Albumin	1.03	1.03–1.04	<0.001
ECD	0.70	0.57–0.86	0.001		DCD	0.44	0.37–0.53	<0.001
HCV seropositive	0.50	0.39–0.64	<0.001		ECD	0.65	0.52–0.81	<0.001
Albumin	1.04	1.03–1.05	<0.001		KDPI	0.99	0.992–0.996	<0.001
KDPI	0.996	0.994–0.997	<0.001		HCV seropositive	0.47	0.35–0.61	<0.001
ECMO	0.67	0.52–0.85	0.001		ECMO	0.64	0.49–0.85	0.002
Open abdomen	0.81	0.69–0.97	0.019		Open abdomen	0.77	0.65–0.92	0.003
Diabetes mellitus	0.63	0.47–0.84	0.002		Death due to cardiovascular cause	0.85	0.77–0.94	0.002
Death due to cardiovascular cause	0.85	0.77–0.94	0.001		Intra-aortic balloon pump	0.69	0.58–0.82	<0.001
Death due to gunshot wound	1.16	1.03–1.31	0.018		Confounders/Interaction terms
Confounders					LRTI	0.90	0.82–0.98	0.019
Length of stay	1.00	0.994–1.01	0.990		MDR-GN by LRTI interaction term	2.31	1.66–3.23	<0.001
Age	0.999	0.997–1.003	0.996

^aThe comparator group in this analysis was comprised of those donors with no MDROs on culture (which could include donors with no positive cultures or those with non-MDRO positive cultures).

^bThe comparator group in this analysis was comprised of those donors with no MDR-GNs on cultures (which could include donors with no positive cultures, those with non-MDRO positive cultures, or those with an MDR-GP on culture).

Abbreviations: CI, confidence interval; DCD, donation after circulatory death; ECD, expanded criteria donor; ECMO, extracorporeal membrane oxygenation; HCV, hepatitis C virus; IRR, incidence rate ratio; KDPI, Kidney Donor Profile Index; MDR-GN, multidrug-resistant Gram-negative; MDRO, multidrug-resistant organism; LRTI, lower respiratory tract infection