Table 3.

Mixed effects multivariable negative binomial regression evaluating the association between the match run at which an organ was accepted and (a) MDRO and (b) MDR-GN on donor hospital cultures

A. MDROa						B. MDR-GNb
Donor characteristic		Relative count	95% CI	P value		Donor characteristic	Relative count	95% CI	P value
MDRO on culture		3.26	0.94–11.28	0.062		MDR-GN on culture	5.08	1.64–15.68	0.005
KDPI		1.02	1.01–1.03	<0.001		KDPI	1.03	1.02–1.04	<0.001
DCD		2.63	1.01–6.86	0.049		HCT	18.91	7.41–48.22	<0.001
Exploratory laparotomy		8.2	1.93–34.83	0.004		Exploratory laparotomy	9.29	2.86–30.19	<0.001
HCV seropositive		0.14	0.069–0.27	<0.001		HBV core antibody positive	2.15	1.03–4.50	0.043
Confounders and interaction terms						HCV seropositive	0.09	0.05–0.19	<0.001
LRTI	1.24		0.79–1.96	0.345		Age	0.97	0.95–0.98	<0.001
MDRO by LRTI interaction	0.12		0.03–0.49	0.003		Confounders and interaction terms
						LRTI	1.18	0.76–1.83	0.47
						MDR-GN by LRTI interaction	0.12	0.03–0.45	0.002
						DCD	1.42	0.40–5.09	0.589
						ECD	1.53	0.71–3.32	0.279
						T4 protocol	0.84	0.29–2.40	0.745

^aThe comparator group in this analysis was comprised of those donors with no MDROs on culture (which could include donors with no positive cultures or those with non-MDRO positive cultures).

^bThe comparator group in this analysis was comprised of those donors with no MDR-GNs on cultures (which could include donors with no positive cultures, those with non-MDRO positive cultures, or those with an MDR-GP on culture).

Abbreviations: CI, confidence interval; DCD, donation after circulatory death; ECD, extended-criteria donor; HBV, hepatitis B virus; HCT, hematopoietic cell transplant; HCV, hepatitis C virus; KDPI, Kidney Donor Profile Index; LRTI, lower respiratory tract infection; MDR-GN, multidrug-resistant Gram-negative; MDRO, multidrug-resistant organism; T4, thyroxine