TABLE 1.
Strain/species sensitivity to anthrax LT, T gondii and DPP8/9 inhibitors
| NLRP1 allele | Strains | Anthrax LT | T gondii | DPP8/9 Inhibitor | ||
|---|---|---|---|---|---|---|
| MΦ pyroptosis | NLRP1 Cleavage | MΦ pyroptosis | Infection sensitivity | MΦ pyroptosis | ||
| Human | ||||||
| N/A | N/A | No | No | High? | Restrictive | Yes |
| Mouse | ||||||
| A | N/A | No | No | NT | Permissive a | Yes |
| B1 | 129S1/SvimJ, BALB/cJ, C3H/HeJ, CBA/J, FVB/NJ, NON/LtJ, NZO/HILtJ, SWR/J | Yes | Yes | Yes | Permissive | Yes |
| B2 | A/J, C57BL/6J, I/LnJ | No | No | Yes | Permissive | Yes |
| B3 | AKR/J, NOD/LtJ, SJL/J (non‐functional) | No | No | NT | NT | No |
| B4 | DBA/2J, P/J, SM/J (non‐functional) | No | NT | NT | Permissive | NT |
| B5 | CAST/EiJ | Yes | Yes | NT | NT | Yes |
| Rat | ||||||
| 1 | BN, WIS, SD, Dahl/SS | Yes | NT | Low | Permissive b | Low |
| 2 | CDF | Yes | Yes | Low | Permissive | Low |
| 3 | ZUC | No | NT | NT | NT | High |
| 4 | COP | No | NT | NT | NT | High |
| 5 | LEW, WKY, SHR, SHR/Lj | No | No | High | Restrictive c | High |
In ref. 50 , OM and DA rats (which express alleles similar to BN) were permissive, and LOU, DBIX and WF (which express alleles similar to LEW) were restrictive. Low and high refer to comparisons between rat strains only. The LT data from refs 17 , 20 , 21 , 34 , 35 , 36 , T gondii from refs 45 , 48 , 49 , 50 , 51 , 53 , 100 , 101 , 102 , DPP8/9 inhibitor data from refs 20 , 56 , 103 . NT, not tested.
a
Mice strains vary in T gondii susceptibility, but are generally more permissive than rats and humans.
b
BN, SD tested.
c
LEW and SHR tested.