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. 2020 Aug 28;11:981. doi: 10.3389/fgene.2020.00981

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Copyright © 2020 Zhu, Jia, Li and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of five hub genes with β-secretase activity and Aβ42 levels using GSE106241. (A) The five hub gene expression, β-secretase activity, and Aβ42 levels in different Braak stages. Red asterisks indicate significant vs. Braak 0 groups. (B) Correlation between five hub genes and β-secretase activity. (C) Correlation between five hub genes and Aβ42 levels. For Panels B and C, P values in red are significant (P < 0.05). *P < 0.05; **P < 0.01; ****P < 0.0001. AD, Alzheimer disease; CN, cognitively normal.