TABLE 1.

Characteristics of the included datasets.

Tissue	Dataset ID	Country	No. of samples	GPL ID	No. of rows per platform	Usage here	References
Temporal cortex	GSE122063	United States	28 AD, 22 CN	GPL16699	62,976	Combined (ComBat) analysis	McKay et al., 2019
Temporal cortex	GSE36980	Japan	10 AD, 19 CN	GPL6244	33,297	Combined (ComBat) analysis	Hokama et al., 2014
Temporal cortex	GSE5281	United States	16 AD, 12 CN	GPL570	54,675	Combined (ComBat) analysis	Liang et al., 2007, 2008a,b; Readhead et al., 2018
Temporal cortex	GSE118553	United Kingdom	52 AD, 31 CN	GPL10558	48,107	WGCNA, GSEA	Patel et al., 2019
Temporal cortex	GSE132903	United States	98 AD, 97 CN	GPL10558	48,107	Validate diff. expr. of hub genes	Piras et al., 2019
Temporal cortex	GSE106241	Finland	60AD	GPL24170	34,487	Hub expr. for Braak, β-secretase, Aβ42	Marttinen et al., 2019
Blood	GSE63060	United Kingdom	145 AD, 80 MCI, 104 CN	GPL6947	49,576	Hub expr. in blood	Sood et al., 2015
Blood	GSE63061	United Kingdom	139 AD, 110 MCI, 135 CN	GPL10558	48,107	Hub expr. in blood	Sood et al., 2015

The first three datasets were used for combined analysis, GSE118553 was used for weighted correlation network analysis (WGCNA) and Gene Set Enrichment Analysis (GSEA), and the last four datasets were used for validating the hub genes. AD, Alzheimer disease; CN, cognitively normal; GSE, Gene Expression Omnibus Series; GPL, Gene Expression Omnibus Platform; MCI, mild cognitive impairment.