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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Neurobiol Aging. 2020 Jun 1;94:101–110. doi: 10.1016/j.neurobiolaging.2020.05.013

Figure 4. Gap termination response (GTR) cells from older 5XFAD mice have lower firing rates than controls.

Figure 4.

A) At 4–6 months of age, baseline firing rates of GTR cells from both male and female 5XFAD mice were significantly lower than those of sex-matched controls. Red asterisks indicate significant differences between 5XFAD and control (rank-sum). Baseline firing rates were measured during background noise in the absence of a gap. Red: 5XFAD, black: control.

B) GTRs in 5XFAD mice from both sexes showed a slight increase followed by a strong decrease compared to controls. In cells from 5XFAD males the decrease was evident at 2–4 months of age, and from females at 4–6 months of age. Blue asterisks indicate a significant increase in 5XFAD GTRs compared to controls, red asterisks indicate a decrease (Kruskal-Wallis).

C) GTRs were reduced across gap durations in male 5XFAD mice. Blue asterisks indicate a significant overall increase in 5XFAD GTRs compared to controls, red asterisks indicate a decrease (Kruskal-Wallis, same as B), grey asterisks indicate significant effects at individual gap durations (post-hoc). Gap durations of 0 ms correspond to baseline firing rates.

D) GTRs were only reduced for brief gap durations in female 5XFAD mice. Values are medians, error bars are IQR.