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. Author manuscript; available in PMC: 2021 Sep 7.
Published in final edited form as: Curr Biol. 2020 Jul 2;30(17):3293–3303.e4. doi: 10.1016/j.cub.2020.06.017

Figure 4. Perturbing auditory cortex inputs into parietal cortex increases auditory integration time.

Figure 4.

A) Schematic of cannula implant over parietal cortex and timeline of experimental test sessions. Infusions of C21 and saline into parietal cortex alternated across test session days. B) Brain slice showing bilateral injections of pAAV-CaMKIIa-hM4D(Gi)-mCherry into auditory cortex. C) High magnification of expanded inset near auditory cortex injection site with labeled cell bodies. D) High magnification of expanded inset in parietal cortex confirms perisomatic labeling (white triangles) from injection sites in B. E) Average psychometric functions across all animals (thick lines) and average psychometric functions from each animal during C21 (purple) and saline (blue) infusion sessions (thin lines). See text for statistical comparisons. F) Distribution of calculated minimum integration times from each animal as a function of infusion condition. Post-hoc analyses revealed minimum integration times under C21 (purple) were significantly different from no drug (black) (two-tailed t-test; Holm-Bonferroni-corrected; p = 0.005, t = 5.61) and saline (blue) (two-tailed t-test; Holm-Bonferroni-corrected; p = 0.003, t = 6.65) sessions. Core auditory cortex (AC), parietal cortex (PC). See also Figure S3 and Figure S4.