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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Exp Eye Res. 2020 May 23;197:108079. doi: 10.1016/j.exer.2020.108079

Figure 6. A schematic of anti-inflammatory mechanisms of 2DG.

Figure 6.

During bacterial endophthalmitis, S. aureus is recognized by TLR2 expressed on innate immune cells, leading to activation of glycolytic and inflammatory (ERK) signaling cascade resulting in induced expression of inflammatory mediators. 2DG exerts anti-inflammatory effects by inhibiting these cellular responses. This schematic was created using BioRender software.