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Ubiquitin modifications in synaptic plasticity and memory formation
| Ubiquitin linkage | Neuronal stimulation | Learning | Critical for memory |
|---|---|---|---|
| Mono | Increase | Increase | Yes - positive regulator |
| Multimono | ? | Decrease | Yes - negative regulator |
| M1/Linear | ? | Increase | ? |
| K6 | ? | ? | ? |
| K11 | ? | ? | ? |
| K27 | ? | ? | ? |
| K29 | ? | ? | ? |
| K33 | ? | ? | ? |
| K48 | Decrease | Increase | Yes - positive regulator |
| K63 | Decrease | Increase | ? |
| Mixed | ? | ? | ? |
| Branched | ? | ? | ? |
