Table 3.
Correlations between the levels of NFL and ALS clinical parameters.
| Clinical parameters | R | p-value |
|---|---|---|
| Age at onset | −0.133 | 0.383 |
| Site of onset | −0.201 | 0.185 |
| Disease duration | −0.190 | 0.212 |
| Diagnostic category | −0.060 | 0.695 |
| Clinical phenotype | −0.050 | 0.743 |
| TTG | −0.339 | 0.123 |
| FVC | −0.154 | 0.350 |
| ALSFRS-r | −0.388 | 0.009 |
| DPR | 0.466 | 0.001 |
ALS, amyotrophic lateral sclerosis; NFL, neurofilament light chain; Disease duration, time from symptom onset to sample collection; ALSFRS-r, revised ALS functional rating scale; DPR, disease progression rate; FVC, forced vital capacity; TTG, the time of symptoms spreading from spinal or bulbar localization to generalization.
The values represent the correlations between NFL level and each clinical parameter.
Correlations were considered significant at p < 0.05. The p < 0.05 was in bold.