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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Clin Pharmacokinet. 2020 Sep;59(9):1085–1107. doi: 10.1007/s40262-020-00898-8

Table 4.

Pharmacodynamic Characteristics of Integrase Strand Transfer Inhibitors

Bictegravir Cabotegravir Dolutegravir Elvitegravir Raltegravir
IC50 (ng/mL) 108 41.4 16 7.2 na
IC90 (ng/mL) na 166 64 na na
IC95 (ng/mL) 162 na na 44.9 14.7
EC50 (ng/mL) na 82 36 14 na
EC90 (ng/mL) na na 324 126 na
IQ(Cthrought / IC90 or 95 13.4 23.7a 17 10 8

Abbreviations: Ctrough, measured concentration at the end of the dosing interval; IC, protein-binding adjusted concentration inhibiting viral replication by 50, 90 or 95% in vitro; EC, concentration producing 50 or 90% effect (reduction of HIV-RNA) in vivo; IQ, inhibitory quotient; na, not available.

a.

IQ is calculated using trough concentrations with 30 mg orally.