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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Free Radic Biol Med. 2020 Jul 23;158:149–161. doi: 10.1016/j.freeradbiomed.2020.07.006

Figure 1.

Figure 1.

Proposed copper coordination modes in α-Syn. (a) Cu(II) coordination at the high-affinity N-terminal site in soluble α-Syn at physiological pH; (b) Cu(I) coordination at the N-terminal site; (c) high affinity N-terminal site in membrane-bound form; (d) NAcα-Syn high-affinity site centered at His50; and (E) low-affinity C-terminal site.