Table 1.
Participant demographics at baseline. Significant findings are baser on three-group ANOVAs or Chi-square tests of independence, with further two-groups post hoc comparisons for significant findings at an alpha level of p<0.05.
| NC (n = 238) | MCI (n = 185) | AD dementia (n = 156) | Between-group differences | |
|---|---|---|---|---|
| Age (SD) | 72.38 (7.69) | 74.99 (7.24) | 76.74 (8.12) | NC < MCI < AD |
| Sex | 62.6% Female | 58.4% Female | 44.2% Female | (NC = MCI) > AD |
| Race | 89.5% White, 9.7% AA, 0.8% Asian |
75.1% White, 23.8% AA, 1.1% Asian |
91.0% White, 7.7% AA, 1.3% Asian |
(NC = AD) > MCI* |
| Education (SD) | 16.56 (2.54) | 15.51 (2.74) | 14.95 (2.95) | NC > (MCI = AD) |
| MMSE (SD) | 29.39 (0.91) | 28.20 (1.67) | 21.11 (6.17) | NC > MCI > AD |
| APOE ε4 carrier status | 77/235 (32.8%) | 59/181 (32.6%) | 88/153 (57.5%) | (NC = MCI) < AD |
| NfL (pg/mL) | 15.33 (10.47) | 17.77 (10.25) | 26.49 (17.30) | NC < MCI < AD |
| t-tau (pg/mL) | 3.22 (2.73) | 3.30 (2.39) | 3.73 (3.01) | not significant |
| # with follow-up | 206 (86.6%) | 150 (81.1%) | 120 (76.9%) | NC > AD |
| Years follow-up (SD) | 5.62 (2.64) | 5.10 (2.78) | 3.20 (2.06) | (NC = MCI) > AD |
AA=African American.
*
Higher proportion of White participants in NC and AD groups compared to MCI.