Table 2.

Post hoc comparisons between participant groups at baseline based on log transformed NfL and t-tau levels (converted to z-scores to facilitate interpretation). All analyses other than AUV are based on ANCOVA models controlling for age, sex, education, race, and APOE ε4 carrier status. Omnibus group effects were significant for both biomarkers.

	Adjusted Difference	95% CI	F	p-value
2.1 NC (n = 238) vs MCI (n = 185)
Baseline NfL	0.10	[−0.05, 0.26]	1.74	.226
Baseline t-tau	0.07	[−0.13,0.27]	0.45	.501
2.2 NC (n = 238) vs AD (n = 156)
Baseline NfL	0.68	[0.49, 0.88]	47.80	< .001
Baseline t-tau	0.33	[0.10, 0.57]	8.07	.010
2.3 MCI (n = 185) vs AD (n = 156)
Baseline NfL	0.55	[0.37, 0.73]	33.70	< .001
Baseline t-tau	0.21	[−0.03, 0.44]	3.01	.126

^*p < .05 after correction for false discovery rate based on six analyses.