TABLE 2.
Results Summary.
| Outcome: Geriatric Depression Scale (GDS) | Unstd. Beta | 95% CI | Z | P Value |
|---|---|---|---|---|
| Model 1: Age and GDS | ||||
| N = 716 (1–13, avg 2.5), df = 3 | ||||
| Sex | 0.15 | −0.36, 0.60 | 0.50 | 0.62 |
| Education | 0.003 | −0.06, 0.06 | −0.02 | 0.98 |
| Age | −0.03 | −0.05, 0.001 | −1.90 | 0.06 |
| Model 2: Age × Time and GDS | ||||
| N = 716 (1–13, avg 2.5), df = 5 | ||||
| Sex | 0.30 | −0.19, 0.80 | 0.33 | 0.23 |
| Education | 0.03 | −0.02, 0.08 | 1.54 | 0.22 |
| Age | −0.02 | −0.68, 0.21 | −2.86 | <0.001 |
| Time | −0.02 | −0.06, 0.02 | −5.73 | 0.41 |
| Age × Time | 0.10 | 0.06, 0.14 | 5.80 | <0.001 |
| Model 3: Age × Fractional anisotropy and GDS | ||||
| N = 359 (1–5 visits, avg 1.6), df=7 | ||||
| Sex | −0.54 | −1.21, 0.12 | −1.60 | 0.11 |
| Education | −0.02 | −0.11, 0.06 | −0.56 | 0.57 |
| Age | −0.04 | −0.08, 0.009 | −1.56 | 0.12 |
| Within-person FA Z-score | 1.70 | 0.282, 3.13 | 2.35 | 0.02 |
| Between-person FA Z-score | −1.30 | −3.73, 1.12 | −1.05 | 0.29 |
| Within-person FA Z-score × age | −0.02 | −0.04, −0.005 | −2.48 | 0.01 |
| Between-person FA Z-score × age | 0.01 | −0.02, 0.05 | 0.72 | 0.47 |
| Model 4: Age × Mean Diffusivity and GDS | ||||
| N = 359 (1–5 visits, avg 1.6), df=7 | ||||
| Sex | −0.62 | −1.301, 0.07 | −1.76 | 0.08 |
| Education | −0.02 | −0.10, 0.06 | −0.43 | 0.66 |
| Age | −0.04 | −0.09, 0.007 | −1.68 | 0.09 |
| Within-person MD Z-score | −1.90 | −3.27, −0.52 | −2.71 | 0.007 |
| Between-person MD Z-score | 0.84 | −1.74, 3.41 | 0.64 | 0.52 |
| Within-person MD Z-score × age | 0.03 | 0.007, 0.05 | 2.70 | 0.007 |
| Between-person MD Z-score × age | −0.006 | −0.04, 0.03 | −0.34 | 0.73 |
| Model 5: Age × Executive Function and GDS | ||||
| N = 716 (1–13, avg 2.5), df=7 | ||||
| Sex | 0.09 | −0.39, 0.56 | 0.36 | 0.72 |
| Education | 0.01 | −0.05, 0.07 | 0.22 | 0.83 |
| Age | −0.04 | −0.06, −0.01 | −2.47 | 0.01 |
| Within-person EF | 2.80 | 0.01, 5.57 | 1.97 | 0.049 |
| Between-person EF | −0.16 | −3.27, 2.94 | −0.10 | 0.92 |
| Within-person EF × age | −0.04 | −0.08, −0.004 | −2.17 | 0.03 |
| Between-person EF × age | −0.01 | −0.05, 0.04 | −0.29 | 0.77 |
| Model 6: Age × Processing Speed and GDS | ||||
| N = 402 (1–5 visits, avg 1.7), df = 7 | ||||
| Sex | −0.43 | −0.97, 0.11 | −1.55 | 0.12 |
| Education | −0.13 | −0.26, 0.01 | −1.88 | 0.06 |
| Age | −0.01 | −0.09, 0.07 | −0.26 | 0.80 |
| Within-person PS | −3.11 | −6.15, −0.06 | −2.00 | 0.046 |
| Between-person PS | 0.42 | −1.76, 2.61 | 0.38 | 0.71 |
| Within-person PS × age | 0.04 | 0.002, 0.08 | 2.04 | 0.04 |
| Between-person PS × age | −0.002 | −0.03, 0.03 | −0.11 | 0.91 |
GDS: Geriatric Depression Scale; EF: executive function; PS: processing speed; FA: fractional anisotropy; GMV: gray matter volume.