4G2 protein is localized in spiral ganglion neurons, nerve fibers and
the auditory nerve in
Ifnar1−/−
ZIKV infected mice. 4G2 is localized in spiral ganglion (SG) neurons
(A”), at a low level within the nerve fiber (nf) region traversed by
spiral ganglion dendrites and olivocochlear efferents beneath the cochlear
epithelium (arrowhead, B”) and within the auditory nerve (AN; arrowheads
indicate examples of immunopositive fibers, C”) in ZIKV infected mice.
4G2 is not detected in spiral ganglion neurons, nerve fibers or the auditory
nerve of vehicle-treated mice (A-C, A’-C’). DAPI counterstains are
shown (A-C, A”’-C”’). Scale bar for A - A” in
A”’, scale bar for B-B”’ in B” and scale bar
for C-C”’ in C”.