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. Author manuscript; available in PMC: 2021 Sep 15.
Published in final edited form as: Hear Res. 2020 Jun 29;395:108000. doi: 10.1016/j.heares.2020.108000

Figure 5.

Figure 5.

Aquaporin-1 localization in the cochlea, scala media and lateral wall of the cochlea in Ifnar1−/− ZIKV infected mice. Vehicle-injected mice show baseline AQP1 localization in type III fibrocytes of the spiral ligament (arrow in A; B) and a low level of protein localization in the endosteum of the scala vestibuli (open arrow in A; B). Postnatal ZKV infection shows upregulation of AQP1 in suprastrial fibrocytes (open arrowhead, C), Type I fibrocytes in the spiral ligament (gray arrow, C), the intermediate region of the stria vascularis (closed arrows, D) and in structures with a vascular appearance in the osseous spiral lamina above the scala vestibuli (open arrows, C). AQP1 is also localized to cells in the scala media (closed arrowheads in C; D) whose nuclei are stained with DAPI (D). Myosin VIIa of inner (gray arrow, B and D) and outer (open arrow, B and D) hairs cells are not double labeled with AQP1 with vehicle treatment (B) or ZIKV infection (D). DAPI counterstains are shown (B, D). Scale bar for A-C in D.