Table 1.

Effect of compounds on lifespan in model organisms

Compound	Mechanisms	C. elegans	Drosophila	Mouse
Metformin	Activates AMPK Activates mTORC1	Increase1	No effect2	Increase3 No effect4
Resveratrol	Activates SIRT1 Activates AMPK Antioxidant Anti-inflammatory	Increase5–8	Increase5, 9	No effect10 Increase11 (mice on high fat diet)
Rapamycin	mTORC1 inhibition	Increase12	Increase13	Increase14–18
N-acetyl-L-cysteine	Antioxidant	Increase19	Increase20	Increase21 (possibly through dietary restriction)
Curcumin	Antioxidant Anti-inflammatory	Increase22	Increase23–26	Increase27 No effect28

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