. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: Mech Ageing Dev. 2020 Jun 28;190:111297. doi: 10.1016/j.mad.2020.111297

Table 2.

Effect of compounds on Alzheimer’s disease

Compound	Cell Culture	C. elegans	Drosophila	Mouse	Human
Metformin	Protective^{1, 2}	Protective³	Protective⁴	Protective^5–10 Deleterious¹¹	Protective^12–16 Deleterious^{17, 18}
Resveratrol	Protective^19–24	Protective²⁵	N/A	Protective^26–32	Protective^{33, 34} No effect³⁵
Rapamycin	Deleterious^{36, 37}	N/A	Protective^{38, 39}	Protective^40–43 Deleterious⁴⁴	N/A
NAC	Protective⁴⁵	N/A	N/A	Protective^{46, 47}	Protective⁴⁸
Curcumin	Protective^{49, 50}	Protective⁵¹	Protective⁵²	Protective^53–55	N/A

^1.

Chen B, et al. (2016) Biomed Res Int 2016.

^2.

Li L-X, et al. (2019) Basic Clin Pharmacol Toxicol 125(5).

^3.

Ahmad W, et al. (2017) Mol Neurobiol 54(7).

^4.

Niccoli T, et al. (2016) Curr Biol 26(17).

^5.

Farr SA, et al. (2019) J Alzheimers Dis 68(4).

^6.

Ou Z, et al. (2018) Brain Behav Immun 69.

^7.

Nassar SZ, et al. (2018) Arch Physiol Biochem.

^8.

Chen J-L, et al. (2019) Experimental neurology 311.

^9.

Zhang J, et al. (2019) FASEB J 33(6).

^10.

Matthes F, et al. (2018) Cell Death Discov 4.

^11.

Barini E, et al. (2016) Mol Neurodegener 11.

^12.

Shi Q, et al. (2019) BMJ Open 9(7).

^13.

Bohlken J, et al. (2018) J Alzheimers Dis 66(2).

^14.

Orkaby AR, et al. (2017) Neurology 89(18).

^15.

Cheng C, et al. (2014) The journals of gerontology. Series A, Biological sciences and medical sciences 69(10).

^16.

Hsu C-C, et al. (2011) J Alzheimers Dis 24(3).

^17.

Imfeld P, et al. (2012) J Am Geriatr Soc 60(5).

^18.

Kuan Y-C, et al. (2017) Prog Neuropsychopharmacol Biol Psychiatry 79(Pt B).

^19.

Marambaud P, et al. (2005) The Journal of biological chemistry 280(45).

^20.

Vingtdeux V, et al. (2010) The Journal of biological chemistry 285(12).

^21.

Granzotto A, et al. (2011) PloS one 6(6).

^22.

Cristòfol R, et al. (2012) Journal of pineal research 52(3).

^23.

Feng X, et al. (2013) PloS one 8(3).

^24.

Wang H, et al. (2018) Toxicology letters 282.

^25.

Regitz C, et al. (2016) European journal of nutrition 55(2).

^26.

Kim D, et al. (2007) The EMBO journal 26(13).

^27.

Karuppagounder SS, et al. (2009) Neurochemistry international 54(2).

^28.

Gong Q-H, et al. (2010) Journal of Health Science 56(6).

^29.

Huang T-C, et al. (2011) PloS one 6(12).

^30.

Porquet D, et al. (2013) AGE 35(5).

^31.

Wang G, et al. (2016) Oncotarget 7(14).

^32.

Capiralla H, et al. (2012) J Neurochem 120(3).

^33.

Turner RS, et al. (2015) Neurology 85(16).

^34.

Moussa C, et al. (2017) Journal of neuroinflammation 14(1).

^35.

Zhu CW, et al. (2018) Alzheimer’s & dementia (New York, N. Y.) 4.

^36.

Yu WH, et al. (2005) J Cell Biol 171(1).

^37.

Lafay-Chebassier C, et al. (2006) J Neurosci Res 84(6).

^38.

Berger Z, et al. (2006) Hum Mol Genet 15(3).

^39.

Khurana V, et al. (2006) Curr Biol 16(3).

^40.

Spilman P, et al. (2010) PLOS ONE 5(4).

^41.

Majumder S, et al. (2011) PLoS One 6(9).

^42.

Caccamo A, et al. (2010) Journal of Biological Chemistry 285.

^43.

Van Skike CE, et al. (2018) Am J Physiol Heart Circ Physiol 314(4).

^44.

Zhang S, et al. (2010) Biochem Biophys Res Commun 398(3).

^45.

Tardiolo G, et al. (2018) Molecules 23(12).

^46.

Costa M, et al. (2016) Chem Biol Interact 253.

^47.

Shahidi S, et al. (2017) Brain Res Bull 131.

^48.

Adair JC, et al. (2001) Neurology 57(8).

^49.

Qian W, et al. (2018) Med Sci Monit 24.

^50.

Reddy PH, et al. (2016) J Investig Med 64(8).

^51.

Kim BK, et al. (2019) Drug Discov Ther 13(4).

^52.

Caesar I, et al. (2012) PLoS One 7(2).

^53.

Ahmed T, et al. (2010) Neuroscience 169(3).

^54.

Frautschy S, et al. (2001) Neurobiology of Aging

^55.

Garcia-Alloza M, et al. (2007) J Neurochem 102(4).