Table 5.

Effect of Compounds on Amyotrophic lateral sclerosis

ALS	Cell Culture	C. elegans	Drosophila	Mouse	Human
Metformin	N/A	N/A	N/A	Deleterious1	No effect2
Resveratrol	Protective3	N/A	N/A	Protective4	N/A
Rapamycin	Protective5	N/A	Protective6	Protective7 No effect8 Deleterious9	In Progress10
NAC	Protective11	N/A	N/A	Protective12	Deleterious13
Curcumin	Protective14, 15	N/A	N/A	N/A	Protective16, 17

^1.Kaneb HM, et al. (2011) PloS one 6(9).

^2.Bond L, et al. (2020) Behavioral Sciences 10(1).

^3.Kim D, et al. (2007) The EMBO journal 26(13).

^4.Mancuso R, et al. (2014) Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 11(2).

^5.Caccamo A, et al. (2009) J Biol Chem 284(40).

^6.Cheng CW, et al. (2015) J Neurogenet 29(2–3).

^7.Wang IF, et al. (2012) Proc Natl Acad Sci U S A 109(37).

^8.Staats KAH, S.; Schonefeldt, S.; Bento-Abreu, A.; Dooley, J.; Van Damme, P.; Liston, A.; Robberecht, W.; Van Den Bosch, L. (2013) Mol Neurodegener 8.

^9.Zhang X, et al. (2011) Autophagy 7(4).

^10.Mandrioli J, et al. (2018) Medicine (Baltimore) 97(24).

^11.Beretta S, et al. (2003) Neurobiology of disease 13(3).

^12.Andreassen OA, et al. (2000) Neuroreport 11(11).

^13.Deepmala, et al. (2015) Neuroscience & Biobehavioral Reviews 55.

^14.Lu J, et al. (2012) Brain Res Bull 89(5–6).

^15.Dong H, et al. (2014) Neuroscience 272.

^16.Ahmadi M, et al. (2018) Neurotherapeutics 15(2).

^17.Chico L, et al. (2018) CNS Neurol Disord Drug Targets 17(10).