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. 2020 Jul 14;585(7823):79–84. doi: 10.1038/s41586-020-2547-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a, Chromosomes and karyotype of CHM13 cell line at passage 10. Mitotic metaphase spreads were prepared from cells treated with colcemid and processed as detailed in Methods. Spectral karyotyping analysis demonstrated normal. 46,XX karyotype. Representative karyotype is shown from one of ten spreads analysed, all ten reported had similar results. Scale bar, 10 μm. b, CHM13 G-banding karyotype. A total of 20 CHM13 metaphase spreads were independently characterized and all showed a similar normal 46, XX female karyotype, as shown.