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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Dev Biol. 2020 Jul 3;465(1):11–22. doi: 10.1016/j.ydbio.2020.06.007

Figure 7. Inhibition of MAPK signaling during vasculogenesis exacerbates angiogenic defects in Etv2- deficient embryos.

Figure 7.

(A-D) Compound microscope images of 48 hpf Tg(kdrl:GFP) wild-type and etv2 MO (5ng)-injected embryos treated either with DMSO or 15μM MAPK inhibitor SL327. Note the severe ISV sprouting defects in etv2 MO + SL327 embryos (D) compared to etv2 MO + DMSO embryos (C). (E,F) Quantitative analysis of ISV number and height. Note the decrease in total number of ISVs (E) and percentage of full sprouts (F) in etv2 MO+SL327 embryos compared to etv2 MO + DMSO embryos. *P<0.05, *** P <0.001. Horizontal bar within violin plots represents median.