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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Dev Biol. 2020 Jul 3;465(1):11–22. doi: 10.1016/j.ydbio.2020.06.007

Figure 8. Model of Ets1 activity and timing.

Figure 8.

(A) Early induction of etv2 expression in lateral plate mesodermal cells by npas4l/cloche. Etv2 initiates the VEGFR2/VEGFA signaling cascade by inducing the expression of kdr and kdrl. (B) Binding of VEGFA ligands to VEGFR2 leads to an increase in downstream MAPK/ERK signaling resulting in the phosphorylation of Ets1. Ets1p (phosphorylated Ets1) induces the expression of kdr and kdrl which creates a positive feedback loop to promote overall endothelial gene expression, endothelial cell differentiation and survival.