(A) Scheme of the variable stress paradigm for female mice. (B-F) Quantification of the behavioral assessment is shown for the four experimental groups: (B) Splash test (one-way ANOVA: F3,39 = 5.33, P = 0.004); (C) NSF test (one-way ANOVA, F3,39 = 5.22, P = 0.004);(D) NSF home cage (one-way ANOVA, F3,39 = 0,6087, P = 0.6137); (E) FST (one-way ANOVA, F3,36 = 2,028, P = 0.1290) (F) Sucrose preference test (one-way ANOVA: F3,36 = 2.491, P = 0.0773). Results are represented as mean ± S.E.M.( *p < 0.05, **P < 0.01, ***P < 0.001; n=8-10 animals/group). NSF: Novelty suppressed feeding; FST: Force swim test; CVS: Chronic Variable Stress.