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HPβCD dose dependently destroyed OHC and IHC beginning in the base and progressing towards the apex. Mean cochleograms showing the percent missing OHC and IHC as a function of percent distance from the apex of the cochlea. Cochlear location related to frequency based on rat cochlear frequency place map on lower kHz-axis as noted in Methods. Three highest doses of HPβCD destroyed IHC as well as OHC.
