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. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: JAMA Neurol. 2020 Aug 1;77(8):1018–1027. doi: 10.1001/jamaneurol.2020.2065

Figure 1. Angiotensin-Converting Enzyme 2 (ACE2) Expression in the Brain.

Figure 1.

Emerging data suggest that ACE2 receptors are expressed in multiple regions of the human and mouse brain, including the motor cortex, posterior cingulate cortex, ventricles, substantia nigra, olfactory bulb, middle temporal gyrus, ventrolateral medulla, nucleus of tractus solitarius, and dorsal motor nucleus of the vagus nerve (A) and on several key cell types that make up the central nervous system, including neurons, microglia, astrocytes, and oligodendrocytes (B).35–37 C, ACE2 receptors on a medullary neuron binding to the SPIKE protein on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).