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. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: JAMA Neurol. 2020 Aug 1;77(8):1018–1027. doi: 10.1001/jamaneurol.2020.2065

Figure 3. Mechanisms of Spread Across the Blood-Brain Barrier.

Figure 3.

A, Infected vascular endothelial cells have been shown to spread severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to glial cells in the central nervous system. B, Known as the Trojan horse mechanism, infected leukocytes can cross the blood-brain barrier to infect the central nervous system. CoV indicates coronavirus.