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. Author manuscript; available in PMC: 2021 Sep 15.
Published in final edited form as: Neuroscience. 2020 Aug 5;444:160–169. doi: 10.1016/j.neuroscience.2020.07.049

Figure 2: High energy collision dissociation (HCD) tandem mass spectrum of human recombinant KAT II treated with GSH and disulfiram.

Figure 2:

Experiments were performed as detailed in the text. The tandem mass spectrum of KAT II, residues X-X, is consistent with the presence of an intramolecular disulfide bond between the two cysteine residues. Fragmentation of the disulfide-linked cysteines resulted in the loss or retention of the sulfur yielding a dehydroalanine (−33.98) and sulfide (31.97), respectively. The asterisk indicates fragment ions in which the sulfur remained on the first cysteine.