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. Author manuscript; available in PMC: 2021 Sep 15.
Published in final edited form as: Neuroscience. 2020 Aug 5;444:160–169. doi: 10.1016/j.neuroscience.2020.07.049

Figure 5: NAC attenuates the neosynthesis of KYNA in the rat mPFC in vivo.

Figure 5:

Microdialysis was performed in awake animals, as described in the text. After 2 h of baseline collection, NAC (125 or 500 mg/kg) or vehicle were administered i.p. twice, i.e. 2 h and 1 h prior to kynurenine (50 mg/kg, i.p.; Kyn) (arrows). Vehicle + Kyn (control): n = 10; NAC (125 mg/kg) + Kyn: n = 7; NAC (500 mg/kg) + Kyn: n = 7, F (2,21)= 9.116 Inset: area under the curve (AUC) of extracellular KYNA levels (mean ± SEM) recovered during 4 h after Kyn administration. *p < 0.05 vs. Kyn, F (2, 21) = 9.338.