Table 1.
Baseline Patient Characteristics by BMPC% Group
| Characteristic | BMPC% <60% (N = 864) | BMPC% ≥60% (N = 562) | P |
|---|---|---|---|
| Age (years) | 66.4 (58.8-73.3) | 66.3 (58.7-73.5) | .7 |
| Male | 531 (61) | 313 (56) | .03* |
| ISS | <.0001* | ||
| 1 | 229 (30) | 73 (14) | |
| 2 | 381 (49) | 184 (35) | |
| 3 | 162 (21) | 272 (51) | |
| R-ISS | <.0001* | ||
| 1 | 116 (18) | 40 (9) | |
| 2 | 483 (74) | 283 (64) | |
| 3 | 51 (8) | 116 (27) | |
| FISH | .0005* | ||
| Standard risk | 419 (82) | 245 (72) | |
| High risk | 91 (18) | 95 (28) | |
| FISH results | |||
| Trisomies | 329 (56) | 226 (56) | .9 |
| t(11;14) | 111 (19) | 85 (21) | .4 |
| t(6;14) | 5 (1) | 6 (1) | .3 |
| t(4;14) | 44 (7) | 43 (11) | .08 |
| t(14;16) | 22 (4) | 24 (6) | .1 |
| t(14;20) | 5 (1) | 5 (1) | .5 |
| 1q+ | 32 (4) | 26 (5) | .4 |
| del(17p)/p53 mutated | 58 (10) | 59 (15) | .02* |
| PCLI | 0.6 (0.2-1.2) | 1.1 (0.6-2.2) | <.0001* |
| Hemoglobin (g/dL) | 11.6 (10.3-13) | 10 (9-11.3) | <.0001* |
| Platelets | 224 × 10^9/1 (176-272) | 201 × 10^9/1 (142-247) | <.0001* |
| WBC | 5.4 × 10^9/l (4.2-7.1) | 5.3 (4-7) | .2 |
| Creatinine (mg/dL) | 0.9 (0.9-1.3) | 1.1 (0.9-1.6) | <.0001* |
| LDH (U/L) | 162 (135-190) | 166 (137-208) | <.0001* |
| M spike (g/dL) | 2.8 (1.9-3.7) | 3.72 (2.5-5.) | <.0001* |
| Abnormal FLC (mg/dL) | 34 (7-124) | 80 (10-303) | <.0001* |
| β2 Microglobulin (μg/mL) | 3.5 (2.57-5.1) | 5.77 (3.8-9.75) | <.0001* |
| Lytic lesions | 478 (63) | 374 (71) | .004* |
| Therapy received | .2 | ||
| ASCT | 308 (36.6) | 184 (33) | |
| IMiD only | 259 (30.8) | 158 (28.4) | |
| PI only | 38 (4.5) | 28 (5) | |
| Alkylator only | 39 (4.6) | 21 (4) | |
| Steroids only | 29 (3.5) | 32 (5.7) | |
| IMiD + PI | 73 (8.7) | 51 (9) | |
| PI + alkylator | 88 (10.5) | 78 (14) | |
| No treatment | 7 (0.8) | 4 (0.9) |
Data are presented as n (%) or median (interquartile range) unless otherwise indicated.
Abbreviations: ASCT = autologous stem-cell transplantation; BMPC% = bone marrow plasma cell percentage; del = deletion; FISH = fluorescence in-situ hybridization; FLC = free light chain; IMiD = immunomodulatory drug; ISS = International Staging System; LDH = lactate dehydrogenase; M = monoclonal; PCLI = plasma-cell labeling index; PI = proteasome inhibitor; R-ISS = Revised International Staging System; WBC = white blood cell.
*
Statistically significant (P < .05).