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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Melanoma Res. 2020 Oct;30(5):455–464. doi: 10.1097/CMR.0000000000000692

Figure 4. Multiple-Interaction gene target model for microRNAs with decreased expression in both hepatic and pulmonary metastases relative to benign nevi and primary cutaneous melanoma.

Figure 4.

Gene targets (circles) of miRs (squares) with significantly decreased expression in pulmonary and hepatic melanoma relative to benign nevi and primary cutaneous melanoma, identified by miRNet with a minimum degree (number of associations with dysregulated microRNAs) of 3. This multiple interaction model is used to demonstrate the potential biological impact of loss of expression of these miRs in metastatic melanoma.