Table 2.
Physico-chemical characteristics and in-vitro aerosolization properties of co-delivery DPI formulations with different initial solid contents in the spray-freeze-drying feed solution (mean ± SD)
| F | Initial solid content (%) | True density (g/cm3)a | ED (Col)b | FPF (Col)b | ED (Iva)b | FPF (Iva)b |
|---|---|---|---|---|---|---|
| F1 | 1.0 | 0.29±0.01 | 95.8±2.1 | 67.8±3.7 | 97.5±1.1 | 75.6±1.0 |
| F2 | 2.0 | 0.31±0.01 | 97.4±1.5 | 73.8±5.2 | 96.4±2.0 | 80.9±4.1 |
| F3 | 3.0 | 0.32±0.02 | 95.3±1.9 | 56.6±2.0 | 96.2±2.9 | 63.2±2.2 |
| F4 | 5.0 | 0.43±0.01 | 96.5±3.4 | 46.4±6.9 | 96.4±3.2 | 38.8±8.8 |
| F5 | 8.0 | 0.56±0.01 | 99.0±1.6 | 28.0±9.8 | 94.7±3.5 | 18.2±6.6 |
| F6 | 10.0 | 0.77±0.02 | 94.9±2.3 | 25.2±2.1 | 91.9±1.3 | 17.4±1.6 |
a
n=5;
b
n=3