Table 1.
Biodistribution comparison between 99mTc(CO)3-NOTA-GGNle-CycMSHhex (NOTA) and 99mTc(CO)3-NODAGA-GGNle-CycMSHhex (NODAGA) on B16/F10 melanoma-bearing C57 mice at 2 h post-injection. The data were presented as percent injected dose/gram or as percent injected dose (Mean ± SD, n = 4)
| Tissues | NOTA | NODAGA |
|---|---|---|
| Percent injected dose/gram (%ID/g) | ||
| Tumor | 19.76 ± 3.62 | 7.19 ± 1.80* |
| Brain | 0.03 ± 0.01 | 0.02 ± 0.01 |
| Blood | 2.19 ± 0.73 | 0.55 ± 0.28* |
| Heart | 0.11 ± 0.07 | 0.15 ± 0.02 |
| Lung | 0.28 ± 0.17 | 0.30 ± 0.13 |
| Liver | 1.57 ± 0.32 | 0.34 ± 0.03* |
| Spleen | 0.38 ± 0.20 | 0.13 ± 0.03 |
| Stomach | 0.50 ± 0.37 | 0.31 ± 0.09 |
| Kidneys | 1.59 ± 0.52 | 8.66 ± 2.59* |
| Muscle | 0.09 ± 0.06 | 0.09 ± 0.03 |
| Pancreas | 0.11 ± 0.06 | 0.10 ± 0.07 |
| Bone | 0.29 ± 0.09 | 0.20 ± 0.06 |
| Skin | 0.35 ± 0.14 | 0.29 ± 0.03 |
| Percent injected dose (%ID) | ||
| Intestines | 2.95 ± 0.25 | 0.56 ± 0.15 |
| Urine | 89.50 ± 2.10 | 92.02 ± 1.36 |
| Uptake ratio of tumor/normal tissue | ||
| Tumor/blood | 9.02 | 13.07 |
| Tumor/kidney | 12.43 | 0.83 |
| Tumor/lung | 70.57 | 23.97 |
| Tumor/liver | 12.59 | 21.15 |
| Tumor/muscle | 219.56 | 79.89 |
| Tumor/skin | 56.46 | 24.79 |
*
p<0.05 for determining significance of differences in tumor, blood, liver and kidney uptake between 99mTc(CO)3-NOTA-GGNle-CycMSHhex and 99mTc(CO)3-NODAGA-GGNle-CycMSHhex.