Table 1.

Association between sensitivity and PPV by study.

Author (year)	Data as observed in publication							Adjusted Malignancy Prevalence of 5%		Adjusted Malignancy Prevalence of 1%		Adjusted Malignancy Prevalence of 0.1%
	Number of Readers	Average Sensitivity (SD)	Average Specificity (SD)	Average Malignancy Prevalence	Positive Predictive Value	Slope Coefficient* (95% CI)	p-value	Slope Coefficient** (95% CI)	p-value	Slope Coefficient** (95% CI)	p-value	Slope Coefficient** (95% CI)	p-value
Monheit (2011)	39 Dermatologists	0.78 (0.13)	0.43 (0.18)	0.50	0.58	−0.49 (−1.26,0.27)	0.20	−1.59 (−4.31,1.13)	0.24	−7.20 (−19.70,5.28)	0.25	−70.53 (−193.0,51.99)	0.25
Ferris (2015)	12 Dermatologists 10 Residents† 8 Physician Assistants	0.71 (0.15)	0.58 (0.18)	0.38	0.53	−1.31 (−2.01,−0.60)	0.001	−3.88 (−5.93,−1.82)	0.001	−17.12 (−26.20, −8.05)	0.001	−166.36 (−254.56,−78.18)	0.001
Marchetti (2018)	8 Dermatologists	0.82 (0.11)	0.60 (0.13)	0.51	0.69	−0.10 (−1.84, 1.64)	0.90	−1.13 (−7.10,4.83)	0.70	−4.99 (−31.59,21.60)	0.66	−48.54 (−307.68,210.60)	0.66
Marchetti (2019)	8 Dermatologists 9 Residents	0.65 (0.17)	0.75 (0.09)	0.33	0.57	0.03 (−1.49, 1.54)	0.97	0.02 (−3.66, 3.69)	0.99	0.03 (−15.53, 15.59)	0.99	0.19 (−149.50, 149.88)	0.99
Tschandl (2019)	283 Dermatologists 118 Residents 83 General Practitioners 27 Not Specified	0.76 (0.13)	0.78 (0.11)	0.36	0.67	0.10 (0.01,0.19)	0.04	−0.001 (−0.09, 0.09)	0.98	0.24 (−0.19,0.67)	0.33	−7.20 (−19.70,5.28)	0.25

^*Slope coefficient for the association between sensitivity and positive predictive value based on the malignancy prevalence observed in the publication

^**Slope coefficient for the association between sensitivity and positive predictive value based on an adjusted malignancy prevalence

^†Unable to extract data from 1 reader

CI = confidence interval; SD = standard deviation