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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Trends Immunol. 2020 Aug 10;41(9):771–784. doi: 10.1016/j.it.2020.07.001

Figure 1.

Figure 1.

Widespread Depletion of Murine Microglia with Orally Administered Colony-Stimulating Factor 1 Receptor (CSF1R) Inhibitors. For illustrative purposes, wild-type mice aged 2 months were treated with the CSF1R inhibitor PLX3397 (600 ppm in chow) for 1, 2, or 7 days. Controls were treated for 7 days with vehicle chow. To visualize microglial depletion, representative micrographs of brain sections stained via chromogenic immunohistochemistry using the common microglial marker ionized calcium binding adaptor molecule 1 (IBA1) are shown. Higher-resolution images are provided as insets. Scale bar, 120 μm.